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By Boschke F.L.

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28. 29. 30. 31. 32. 33. 47 Ute Bahr and Hans-Rolf Schulten 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. , K/immler, D. : Anal. Chim. Acta 113, 253 (1980) Johnson, F. N. ): Lithium research and therapy. , Becker, B. F. : Pfliigers Arch. 370, 211 (1977) Ebstein, R. , Belmaker, R. : J. Pharm. Pharmacol. 30, 122 (1978) Lehmann, W. -R. : Biomed. Mass Spectrom. 5, 536 (1978) Hamilton, E. , Miuski, M. , Clary, J. : Sci. Total Environ, 1, 341 (1972) Welz, B.

5 min Cs @ Heart muscle after 30 rain Cs @ Purkinje fiber after 30 min Cs These relatively high concentrations measured by FDMS can also be detected by other methods with adequate accuracy, although the FD method has the advantage that tissues need no pretreatment. Parallel measurements of the same preparations by atomic absorption and emission spectroscopy have revealed no significant deviations from the authors' results. Hence, Purkinje fibers take up so much cesium after the application of a cesium solution described above that the intracellular cesium concentration is still about 100 times higher after wash-out than under normal conditions.

In order to determine the distribution of thallium with time in an organism we administered orally 160 mg of thallium per kg body weight to mice. After fixed periods of time the acutely poisoned mice were killed and the thallium concentrations in the heart, liver, kidney and brain were determined by FDMS (Fig. 19). According to the results it would appear that the brain possesses an inbuilt barrier for thallium, which however, breaks down as a function of dosage after loss of the excretory function of the kidney (see curves a and b in Fig.

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